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KMID : 0367419940370030368
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Journal of Korean Pediatric Society
1994 Volume.37 No. 3 p.368 ~ p.375
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The Effect of Long-term Phenobarbital Administration on the Bone Mineral Density of Children
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서윤석
김영국/이정화/유기환/이주원/독고영창
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Abstract
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The long term administration of anti-convulsants on children with convulsive disorders may cause osteomalacia, depending on the dosage, duration, type and combination of anti-convulsants administred. Fifteen children, comprising 10 male and 5
female,
dignosed with convulsive disorders and administered with phenobarbital for a long term period of more than 9 months but less than 84 months and 15 healthy children of a similar age-group were selected for the investigation the density of she
spinal
backbone of each individual was measured by means of the "QDR-2000 X-ray bone densitometer's (made by Hologic company) which uses the double energy X-ray absorption technique. The levels of serum calcium, phosphrus and alkaline phosphatase for
each
child were also measured for comparative analysis.
@ES The results were as follows:
@EN 1) The mean bone density for the healthy group of chlidren was 0.69±0.09g/㎠ and that for the group of children administered with phenobarbital was 0.59±0.07㎠ indicating a significant decrease in density for the latter group (p<0.05).
2) As for the relationship between the duration of phenonbarbital and the decrease in bone mineral density, 5 of 6 patients(83%) administered with phenobarbital for more than 4 years showed a decrease in bone mineral density and 5 of 9 patients
(56%)
administered with phenobarbital for less than 4 years showed a decrease in bone mineral density.
3) the mean vitamin D level for the healthy group of chlidren was 26.8±2.5pg/ml indicating a significant decrease in vitamin D3 level for this group(p<0.05).
4) The mean serum alkaline phospatase evel for the health group of children was 240±50u/L and 462±110u/L for those administered with phenobarbital. This indicate a significant increase in ALP for phenobarbital group(p<0.05).
5) The posphorus and calcium levels were within the normal range for all the groups of children.
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KEYWORD
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